Christina Applegate, who has candidly shared raw details about her journey with multiple sclerosis for years, revealed Monday (Oct 19) that her doctor says she doesn’t have the autoimmune disease and was misdiagnosed.

“I’m back at square one where I don’t know what’s going on with me,” the actor said on the latest edition of her podcast MeSsy, along with co-host Jamie-Lynn Sigler, who has been public about her own battle with MS.

Applegate first publicly announced in 2021 that she had been diagnosed with the disorder that causes the immune system to attack the cells in the central nervous system.

On Monday’s podcast, Applegate revealed that despite the misdiagnosis, she still has “every symptom of someone with MS,” adding, “I still have to use wheelchairs when I go to the doctor’s office. I can’t walk from the car to the room.”

Recalling the moment her doctor delivered the news, Applegate said: “She came into my room and said, ‘Congratulations, you don’t have MS.’ I was, like, not happy at all. Everybody else was so happy.”

“You don’t get misdiagnosed and then all of a sudden I’m better,” she added. “I haven’t gotten better, Jamie! If anything, I’ve gotten worse.”

There is no single test for MS, and a diagnosis usually involves ruling out other causes. It can take years and seeing multiple doctors before one puts the clues together.

Applegate said the news had put her in an odd place since she and Sigler have become prominent advocates for people with MS.

“It’s weird because I feel like I let everybody down,” she said. “It’s very unnerving, and it’s really confusing for me.”

She also said the misdiagnosis has left her searching for answers. “That’s going to be an online investigation my doctors are going to get into just to find out what has been going on since 2021, why did this happen?”