Antony Blinken says Israel has not informed the US of any specific date for a major offensive into the southern Gaza city of Rafah.
Israel has said for weeks it will launch an incursion into Rafah, which it says is the last stronghold of Hamas.
But even its closest allies, including the US, have urged against an offensive and warned it will cause a large number of civilian casualties.
The US secretary of state said American and Israeli officials were in close contact to try to ensure “any kind of major military operation doesn’t do real harm to civilians”.
About 1.4 million Palestinians are in Rafah, many displaced from other parts of Gaza.
‘Fourteen killed in Israeli airstrike’ ahead of Eid
An Israeli airstrike on a residential building in central Gaza has killed 14 people, according to a local hospital.
Most of those killed were women and children and 30 others were seriously injured, al Aqsa Martyrs Hospital spokesperson Dr Khalil al Dikran told CNN.
The building was inside the Nuseirat refugee camp.
The attack happened on the last night before Eid al Fitr, which marks the end of Ramadan.
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